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thymus-independent antigen [1 record]

Record 1 2006-05-18

English

Subject field(s)
  • Immunology
DEF

An antigen which does not require T lymphocyte participation to elicit an immune response in B lymphocytes. Animals lacking a thymus can respond to these antigens.

DEF

An antigen that can trigger B cells to produce antibodies without the participation of T cells; most are polymers with a simple repeating pattern and are B cell mitogens; only IgM is produced and few memory cells are formed.

CONT

T-independent antigens can directly stimulate B cells....

French

Domaine(s)
  • Immunologie
DEF

Antigène vis-à-vis duquel la production des anticorps (essentiellement IgM) ne nécessite pas la présence des cellules T. La production de ces anticorps n'est cependant pas strictement thymo-indépendante car elle peut être soumise à l'action régulatrice de cellules T suppressives et amplificatrices.

CONT

Antigènes thymo-indépendants: Type 1 (T.I.-1) : lipopolysaccharides (LPS), flagelline polymérisée, polyvinylpyrrolidone; Type 2 (T.I.-2) : polysaccharides solubles (par ex. polysaccharides SIII polymères synthétiques de D-acides aminés. (J.-F. Bach, P. Lesavre, Op. cit. p. 43.

Spanish

Campo(s) temático(s)
  • Inmunología
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